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当前位置: 首页 > 产品中心 > Genetic_mutations > AbD-Serotec/Palivizumab抗体| AbD23967 | hIgG1/0.1 mg/HCA262P
商品详细AbD-Serotec/Palivizumab抗体| AbD23967 | hIgG1/0.1 mg/HCA262P
AbD-Serotec/Palivizumab抗体| AbD23967 | hIgG1/0.1 mg/HCA262P
AbD-Serotec/Palivizumab抗体| AbD23967 | hIgG1/0.1 mg/HCA262P
商品编号: HCA262P
品牌: AbDSerotec
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 基因突变
公司分类: Genetic_mutations
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Human anti Palivizumab, clone AbD23967_hIgG1, is a paratope specific, high affinity, anti-idiotypic antibody that specifically recognizes the monoclonal antibody drug palivizumab and inhibits it binding to its target. The antibody can be used to measure the levels of palivizumab and biosimilar products in bioanalytical assays.Clone AbD23967_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a reference standard in an anti-drug antibody (ADA) assay. Additionally the antibody can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody is recommended as the detection antibody and is available unlabeled or directly conjugated to HRP. Use in a pair with capture antibody clone AbD23967 (HCA261) in monovalent Fab format.Palivizumab (Synagis®) is a humanized mouse monoclonal antibody (IgG1/kappa) specific to an epitope of the F protein of respiratory syncytial virus (RSV). It binds the antigenic site A, a highly conserved region on the RSV F protein between amino acids 258 and 275. RSV is known to cause infections of the lower respiratory tract in a clear seasonal pattern during the winter months. Administration of the drug is recommended for premature infants (under 35 weeks gestation), infants with certain congenital heart defects (CHD) or bronchopulmonary dysplasia (BPD) throughout the duration of the RSV season. It is approved by the FDA and EMA as a treatment for respiratory tract infection caused by RSV.View a summary of all anti-palivizumab antibodies

Product Details

Product Form
Human IgG1 antibody selected from the HuCAL® phage display library and expressed in a human cell line. Conjugated to horseradish peroxidase (HRP) - liquid.
Product Form
Human IgG1 antibody selected from the HuCAL® phage display library and expressed in a human cell line.
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.01% Thiomersal
Preservative Stabilisers
0.01% Thiomersal
Immunogen
Palivizumab
Affinity
The monovalent intrinsic affinity of this antibody was measured as KD = 1.5 nM by real time, label free molecular interaction analysis on immobilized palivizumab.
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Approx. Protein Concentrations
Antibody concentration 0.5 mg/ml

Storage Information

Storage
Store at -70oC.Storage in frost-free freezers is not recommended.This product should be stored undiluted.
Storage
Store at +4oC or at -20oC if preferred.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch
Guarantee
12 months from date of despatch

More Information

Acknowledgements
Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany. Synagis® is a registered trademark of the AstraZeneca group of companies.
Acknowledgements
Sold under license of U.S. Patents 6753136, 7785859 and 8273688 and corresponding patents. This antibody was developed by Bio-Rad, Zeppelinstr. 4, 82178 Puchheim, Germany.
Licensed Use
For in vitro research purposes and for commercial applications for the provision of in vitro testing services to support preclinical and clinical drug development. Any re-sale in any form or any other commercial application needs a written agreement with Bio-Rad.
Regulatory
For research purposes only

Applications of Palivizumab antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application NameVerifiedMin DilutionMax Dilution
ELISA
ELISA
      Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
      Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
      Technical Advice
      Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
      Technical Advice
      Recommended protocols and further information about HuCAL recombinant antibody technology can be found in theHuCAL Antibodies Technical Manual
      ELISA
      This product may be used as a detection reagent in a sandwich ELISA together with HCA261 as the capture reagent.Protocol: PK bridging ELISA to measure free drug
      ELISA
      This product may be used in direct or indirect ELISA and in an ELISA bridging assay as a capture or detection antibody together with the same antibody or HCA261 as the paired reagent. It is also suitable as a fully human control or calibrator antibody in an ADA bridging ELISA.Protocol: PK bridging ELISA to measure free drug

      Useful Reagents Available

      DescriptionProduct CodeApplicationsPack SizeList PriceQuantity
      Hispec Assay DiluentBUF049AEIY 50 ml
      Human anti PalivizumabHCA261E 0.1 mgloader
      Human anti PalivizumabHCA262E 0.1 mgloader
      Hispec Assay DiluentBUF049AE IY 50 ml
      Human anti PalivizumabHCA261E 0.1 mgloader
      LYNX Rapid HRP Antibody Conjugation KitLNK002P CJ 3 Conjugations For 400µg Antibody

      Product Specific References

      References for Palivizumab antibody

      1. Kashiwagi, N. et al. (2017) Method for measuring anti-drug antibodyUS Patent Application US20170315118A1
      View more products with Palivizumab specificity
      品牌介绍
      AbD Serotec一抗以高特异性和亲和力直接结合特异性抗原。它们可以是与特定表位结合的单克隆抗体,也可以是与抗原的几个表位结合的多克隆抗体。一抗主要用于免疫测定,例如ELISA,蛋白质印迹,免疫组织化学,染色质免疫沉淀(ChIP)或流式细胞仪。对于抗原检测,可以将一抗结合到报告酶或荧光团上,这有助于定量或分析抗原表达。共轭一抗体通常消除了对二抗体的需求 ; 但是某些实验条件可能需要使用它们。针对纯化的一抗的Fc部分开发了二抗,通常将二抗结合用于抗原检测。另外,它们针对第一抗体的宿主物种而开发,使得在山羊中产生的第一抗体将需要在除山羊以外的物种中产生的抗山羊第二抗体。多克隆抗体由免疫球蛋白分子的混合池组成,这些免疫球蛋白分子与单个抗原上的几种不同表位结合。多克隆抗体通常在兔,驴,绵羊和山羊中产生,并从血清中纯化。相反,单克隆抗体结合靶抗原内的单个表位。